p-Toluenesulfonic acid → HCID 25120533, compound

Participants

Reaction Steps

To a solution of 3-({1-[(benzylamino)methyl]-7-(trifluoromethyl)imidazo[1,2-a]quinoxalin-4-yl}amino)propan-1-ol (23 mg, 0.05 mmol) in methanol (600 μL) were added 5% Pd/C (21 mg, 0.01 mmol) and para-toluenesulfonic acid (2 mg, 0.01 mmol). The mixture was stirred under one hydrogen atmosphere for 4 days at room temperature. The reaction mixture was filtered on Celite and rinsed with methanol and dichloromethane. The crude product was purified by preparative TLC (dichloromethane/methanol 9/1) to give the title compound (8 mg, 43%) as a colorless oil.

Provenance & Evidence