Tetrahydrofuran → HCID 178468649, compound

Participants

Reaction Steps

A mixture of 3-(7-Trifluoromethyl-1-trimethylsilanylethynyl-imidazo[1,2-a]quinoxalin-4-ylamino)-propan-1-ol (0.37 mmol; 150 mg), ethyl diazoacetate (0.93 mmol; 0.10 mL), and CsF (0.55 mmol; 84 mg), in THF (0.2 mL) under argon was stirred at 85° C. for 20 hr. After concentration in vacuo, the residue was purified by preparative TLC (dichloromethane/methanol) to yield the title compound as a white powder (58 mg; 0.13 mmol; 35%).

Provenance & Evidence