Iodine → HCID 59333310, compound

Participants

Reaction Steps

To a mixture protected from light of Selectfluor (103 mg; 0.29 mmol; 1.4 eq) and iodine (63 mg; 0.248 mmol; 1.2 eq) in acetonitrile (1.8 ml) stirred for 10 min under argon is added 3-({7-[2-(trifluoromethyl)phenyl]imidazo[1,2-a]quinoxalin-4-yl}amino) propan-1-ol (80 mg; 0.207 mmol; 1 eq) prepared as in example 5. The reaction mixture is stirred at rt overnight. Filtration of solid side-products, concentration, dissolution in ethyl acetate, washing with brine, aqueous sodium carbonate and water, drying (magnesium sulphate) and purification by prep CCM on silicagel (dichloromethane/methanol 95:5) affords the title product as an orange oil (88 mg; 0.17 mmol; 82%).

Provenance & Evidence