Sodium Carbonate → HCID 25120170, compound

Participants

Reaction Steps

A solution of 3-({1-iodo-7-[2-(trifluoromethyl)phenyl]imidazo[1,2-a]quinoxalin-4-yl}amino)propan-1-ol (42 mg; 0.082 mmol; 1 eq), 1,1′bis(diphenylphosphino) ferrocene)palladium dichloride. dichloromethane complex (20.1 mg; 0.025 mmol; 0.3 eq), 1H-pyrazole-5-boronic acid (18.3 mg; 0.164 mmol; 2 eq) and sodium carbonate (26 mg; 0.246 mmol; 3 eq) in anhydrous dimethylformamide (0.37 ml) is stirred under argon at 100° C. for 4 h. Partition (aqueous sodium hydrogenocarbonate/ethyl acetate), filtration over Celite, extraction of the aqueous phase (ethyl acetate), reunion of the organic phases, drying (magnesium sulphate) and purification by prep CCM on silicagel (dichloromethane/methanol 95:5) affords the title product (15 mg; 0.033 mmol; 39%) as an off-white solid.

Provenance & Evidence