反应详情

A solution of N-benzyl-5-(1H-imidazol-1-yl)-2-(trifluoromethyl)benzene-1,4-diamine (160 mg; 0.48 mmol; 1 eq) and carbonyl diimidazole (156 mg; 0.96 mmol; 2 eq) in 1,2-dichlorobenzene (20 ml) is stirred under argon at reflux for 3 h. Concentration, filtration over a small silicagel pad with ethyl acetate as eluent and purification by prep CCM on silicagel (ethyl acetate) affords the title product (72 mg; 0.2 mmol; 42%) as a pale yellow solid.

1. temperatureat reflux for 3 h
2. concentrationConcentration, filtration over a small silicagel pad with ethyl acetate as eluent
3. custompurification by prep CCM on silicagel (ethyl acetate)