Hydrochloric Acid → 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To methyl 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylate (900 mg, 3.98 mmol) was added 12% aqueous KOH (5 mL), and the resulting reaction mixture was stirred at 80° C. for 30 min. The reaction mixture was poured into 1N aqueous HCl (excess), the aqueous phase was extracted 3 times with dichloromethane, the combined organic layers was dried and concentrated under vacuum to afford 5-tert-butyl-2-nitro-1H-pyrrole-3-carboxylic acid (5) as yellow solid (750 mg, 89%).

Provenance & Evidence