1-Pyrrolidineethanamine → HCID 58135338, compound

HRID 1893584Notes

Reaction equation

HRID 1893584 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:27])=[C:6]([N:8]([CH2:13][C:14]([N:16]([N:18]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19]2)[CH3:17])=[O:15])[CH2:9][C:10](O)=[O:11])[CH:7]=1.[NH2:28][CH2:29][CH2:30][N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:27])=[C:6]([N:8]([CH2:13][C:14]([N:16]([N:18]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19]2)[CH3:17])=[O:15])[CH2:9][C:10]([NH:28][CH2:29][CH2:30][N:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)=[O:11])[CH:7]=1

Participants

3

Reactant 2

HCID 13441-PyrrolidineethanamineHCID 66880893HCID 66880893, compound

Product 1

HCID 58135338HCID 58135338, compoundYield 74%

Procedure

Using the compound (300 mg, 0.77 mmol) obtained in step A, and 1-(2-aminoethyl)pyrrolidine (0.11 ml, 0.85 mmol), and according to the method of Example 1, step B, the title compound (275 mg, yield 74%) was obtained as a pale-yellow amorphous solid.

Sources & evidence

ORD record
ord-da3219a517d246d395ee5f2bdccc49fe
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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