N-BOC-ethylenediamine → HCID 131730816, compound

HRID 1893586Notes

Reaction equation

HRID 1893586 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:27])=[C:6]([N:8]([CH2:13][C:14]([N:16]([N:18]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19]2)[CH3:17])=[O:15])[CH2:9][C:10]([OH:12])=O)[CH:7]=1.[NH2:28][CH2:29][CH2:30][NH:31]C(=O)OC(C)(C)C>>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:27])=[C:6]([N:8]([CH2:13][C:14]([N:16]([N:18]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19]2)[CH3:17])=[O:15])[CH2:9][C:10]([NH:28][CH2:29][CH2:30][NH2:31])=[O:12])[CH:7]=1

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 66880893HCID 66880893, compound

Product 1

HCID 131730816HCID 131730816, compoundYield 215.5%

Procedure

Using the compound (400 mg, 1.03 mmol) of Example 45, step A, and tert-butyl (2-aminoethyl)carbamate (215 mg, 1.34 mmol), and according to the methods of Example 1, steps B and C, the title compound (372 mg, yield 72%) was obtained as a colorless solid.

Sources & evidence

ORD record
ord-f985203e75af4cc197456b313ca8165d
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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