2,2-Difluoroethyl trifluoromethanesulfonate → HCID 66880834, compound

HRID 1893599Notes

Reaction equation

HRID 1893599 reaction equation
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][N:6]([CH2:17][C:18]([N:20]([N:22]1[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][C:28]=2[F:31])[CH2:23]1)[CH3:21])=[O:19])[C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[CH3:16])[NH:12][N:11]=[CH:10]2)[CH3:2].FC(F)(F)S(O[CH2:39][CH:40]([F:42])[F:41])(=O)=O>>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][N:6]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:15]=1[CH3:16])[N:12]([CH2:39][CH:40]([F:42])[F:41])[N:11]=[CH:10]2)[CH2:17][C:18]([N:20]([N:22]1[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][C:28]=2[F:31])[CH2:23]1)[CH3:21])=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 66882162HCID 66882162, compound

Product 1

HCID 66880834HCID 66880834, compoundYield 70.2%

Procedure

Using the compound (909 mg, 2.07 mmol) of step A and 2,2-difluoroethyl trifluoromethanesulfonate (612 mg, 2.86 mmol), and according to the method of Example 241, step C, the title compound (732 mg, yield 70%) was obtained as a colorless amorphous solid.

Sources & evidence

ORD record
ord-dfa6a9311ba24c73b3987d385de84e9c
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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