Ethyl 2-bromo-1,3-thiazole-4-carboxylate → HCID 123981943, compound

HRID 1893610Notes

Reaction equation

HRID 1893610 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[N:10]([CH3:46])[C:11](=[O:45])[CH2:12][N:13]([C:30]1[CH:35]=[CH:34][C:33](B2OCC(C)(C)CO2)=[CH:32][C:31]=1[CH3:44])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:21][CH3:22])=[O:16].Br[C:48]1[S:49][CH:50]=[C:51]([C:53]([O:55][CH2:56][CH3:57])=[O:54])[N:52]=1>>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][N:2]1[N:10]([CH3:46])[C:11](=[O:45])[CH2:12][N:13]([C:30]1[CH:35]=[CH:34][C:33]([C:48]2[S:49][CH:50]=[C:51]([C:53]([O:55][CH2:56][CH3:57])=[O:54])[N:52]=2)=[CH:32][C:31]=1[CH3:44])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:24])[CH2:21][CH3:22])=[O:16]

Participants

3

Reactant 2

HCID 353965Ethyl 2-bromo-1,3-thiazole-4-carboxylateHCID 86650793HCID 86650793, compound

Product 1

HCID 123981943HCID 123981943, compoundYield 52%

Procedure

Using the compound (510 mg, 0.802 mmol) of Example 295, step A and ethyl 2-bromothiazole-4-carboxylate (227 mg, 0.962 mmol), and according to the method of Example 295, step B, the title compound (282 mg, yield 52%) was obtained as a brown oil.

Sources & evidence

ORD record
ord-54649dcb0245488183f882e784b8abcd
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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