5-Oxo-pyrrolidine-3-carboxylic acid methyl ester → HCID 123520718, compound

HRID 1893613Notes

Reaction equation

[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[N:10]([CH3:39])[C:11](=[O:38])[CH2:12][N:13]([C:30]1[CH:35]=[CH:34][C:33](I)=[CH:32][C:31]=1[CH3:37])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:21][CH3:22])=[O:16].[O:40]=[C:41]1[NH:45][CH2:44][CH:43]([C:46]([O:48][CH3:49])=[O:47])[CH2:42]1>>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[N:10]([CH3:39])[C:11](=[O:38])[CH2:12][N:13]([C:30]1[CH:35]=[CH:34][C:33]([N:45]2[CH2:44][CH:43]([C:46]([O:48][CH3:49])=[O:47])[CH2:42][C:41]2=[O:40])=[CH:32][C:31]=1[CH3:37])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:21][CH3:22])=[O:16]

Participants

Reactant 2

HCID 131181175-Oxo-pyrrolidine-3-carboxylic acid methyl ester

HCID 123606779HCID 123606779, compound

Product 1

HCID 123520718HCID 123520718, compoundYield 72.2%

Procedure

Using the compound (650 mg, 1.00 mmol) of Example 293, step A and methyl 5-oxopyrrolidine-3-carboxylate (215 mg, 1.50 mmol), and according to the method of Example 298, step A, the title compound (480 mg, yield 72%) was obtained as a brown oil (480 mg).

Sources & evidence

ORD record: ord-2ef350273399418985f8af7a27773fc4
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513235B2

Reaction notes

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