Ethyl 2-bromothiazole-5-carboxylate → HCID 124006210, compound

HRID 1893614Notes

Reaction equation

HRID 1893614 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[N:10]([CH3:46])[C:11](=[O:45])[CH2:12][N:13]([C:30]1[CH:35]=[CH:34][C:33](B2OCC(C)(C)CO2)=[CH:32][C:31]=1[CH3:44])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:21][CH3:22])=[O:16].Br[C:48]1[S:49][C:50]([C:53]([O:55][CH2:56][CH3:57])=[O:54])=[CH:51][N:52]=1>>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[N:10]([CH3:46])[C:11](=[O:45])[CH2:12][N:13]([C:30]1[CH:35]=[CH:34][C:33]([C:48]2[S:49][C:50]([C:53]([O:55][CH2:56][CH3:57])=[O:54])=[CH:51][N:52]=2)=[CH:32][C:31]=1[CH3:44])[CH2:14][C:15]([NH:17][CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:27])[CH3:28])=[O:24])[CH2:21][CH3:22])=[O:16]

Participants

3

Reactant 2

HCID 3614103Ethyl 2-bromothiazole-5-carboxylateHCID 86650793HCID 86650793, compound

Product 1

HCID 124006210HCID 124006210, compoundYield 14%

Procedure

Using the compound (1.69 g, 2.66 mmol) of Example 295, step A and ethyl 2-bromothiazole-5-carboxylate (754 mg, 3.19 mmol), and according to the method of Example 295, step B, the title compound (246 mg, yield 14%) was obtained.

Sources & evidence

ORD record
ord-d4b925f8949e4280a1f400b01aac2043
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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