2,2-Difluoroethan-1-ol → 2,2-Difluoroethyl sulfamate

HRID 1893623Notes

Reaction equation

HRID 1893623 reaction equation
C1([O:4][S:5](=[O:8])(=[O:7])[NH2:6])CC1.[F:9][CH:10]([F:13])[CH2:11][OH:12]>>[F:9][CH:10]([F:13])[CH2:11][NH:6][S:5](=[O:8])(=[O:7])[O-:4].[F:9][CH:10]([F:13])[CH2:11][O:12][S:5](=[O:7])(=[O:4])[NH2:6]

Participants

4

Reactant 2

HCID 1361872,2-Difluoroethan-1-olHCID 57785190Cyclopropyl sulfamate

Product 2

HCID 577851552,2-Difluoroethyl sulfamateHCID 86632791N-(2,2-difluoroethyl)sulfamate

Procedure

2,2-Difluoroethylsulfamate was synthesized according to the method presented in the synthesis of sulfamic acid cyclopropyl ester in Example 1 with the exception of utilizing 2,2-difluoroethylalcohol to obtain sulfamic acid 2,2-difluoro-ethyl ester.

Sources & evidence

ORD record
ord-aa467c02de7f46f1a792388493d9d9a2
Source dataset
uspto-grants-2013_08
Patent number
US08513186B2

Reaction notes

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