Phenylsulfamate → Sulfamic acid 1-trifluoromethyl-cyclobutyl ester

HRID 1893647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1893647
C1([O:7][S:8](=O)(=[O:10])[NH2:9])C=CC=CC=1.[F:12][C:13]([F:20])([F:19])[C:14]1([OH:18])[CH2:17][CH2:16][CH2:15]1>>[F:12][C:13]([F:20])([F:19])[C:14]1([O:18][S:8](=[O:10])(=[O:7])[NH2:9])[CH2:17][CH2:16][CH2:15]1

Komponenten

3

Edukt 2

HCID 11030308PhenylsulfamateHCID 574451561-(Trifluoromethyl)cyclobutanol

Produkt 1

HCID 57785580Sulfamic acid 1-trifluoromethyl-cyclobutyl ester

Versuchsvorschrift

Sulfamic acid 1-trifluoromethyl-cyclobutyl ester was synthesized according to the method presented in the synthesis of sulfamic acid phenyl ester in Example 1 with the exception of utilizing 1-trifluoromethyl-cyclobutanol to obtain sulfamic acid 1-trifluoromethyl-cyclobutyl ester: 1H NMR (CDCl3, 300 MHz) δ 5.85 (s, 2H), 3.40 (t, 1H), 3.01 (m, 1H), 2.56 (m, 1H), 2.42 (t, 1H), 2.04 (m, 1H), 1.85 (m, 1H).

Aufarbeitung

  1. customSulfamic acid 1-trifluoromethyl-cyclobutyl ester was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-dd4cb3ce42e1499f8a614012953850d2
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08513186B2

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