HCID 178477333, compound → HCID 178477297, compound

Participants

Reaction Conditions

Reaction Steps

8-Chloro-2-ethylsulfanyl-4-hydroxy-quinoline-3-carboxylic acid (17.17 g, 60.52 mmol) was suspended in diphenyl ether (250 mL) and heated to 250° C. for 30 minutes and the mixture was then cooled down to room temperature. The mixture was directly transferred onto a load cartridge and purified by column chromatography to afford 8-chloro-2-ethylsulfanyl-quinolin-4-ol (12.36 g, 85% yield). 1H NMR (CDCl3, 300 MHz) δ 8.25 (d, 1H), 7.70 (d, 1H), 7.32 (t, 1H), 6.52 (s, 1H), 3.18-3.11 (m, 2H), 1.54-1.44 (m, 3H). LCMS found 240.17 [M+H]+.

Provenance & Evidence