4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one → 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one

Participants

Reaction Steps

To 4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one (120 mg) in methanol (10 mL) was added Pd catalyst (10% on carbon, 60 mg) and the resulting reaction mixture was stirred under H2 at 60 psi for overnight. After the solids were removed by filtration over Celite, the solvent was removed in vacuo to afford 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one 7 as a yellow film (100 mg, 92%).

Provenance & Evidence