Methanol → HCID 68795508, compound

Participants

Reaction Steps

To 14-tert-Butoxycarbonylamino-18-(4-fluoro-1,3-dihydro-isoindole-2-carbonyloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid methyl ester (916 mg, 1.43 mmol) in a 1:1:1 mixture of THF:MeOH:H2O (12 mL) was added lithium hydroxide (299 mg, 41.96 mmol). The resulting slurry was stirred at room temperature overnight then diluted with EtOAc and washed with 1 N HCl and brine. The resulting organic layer was dried over sodium sulfate and concentrated to provide the crude 14-tert-Butoxycarbonylamino-18-(4-fluoro-1,3-dihydro-isoindole-2-carbonyloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid (910 mg, 100% yield). LCMS found 628.8 [M+H]+.

Provenance & Evidence