Hydrochloric Acid → HCID 178490772, compound

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Reaction Steps

According to Scheme 2, Step 4: To a solution of 1-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl)-2-thiocyanatoethanone (6.57 mmol, 1.98 g) in EtOH was added HCl concentrated (1 mL) and the reaction mixture was stirred under reflux for 8 hours. After cooling to room temperature, the solvent was removed under reduced pressure and the residue was diluted with water. The aqueous phase was basified with NaOH and was extracted with DCM. The organic phase was dried over MgSO4, was filtered and was evaporated. The crude residue was purified by flash chromatography over silica gel using DCM/EtOH/NH3 (100:0:0 to 95:4.5:0.5) as eluent to yield 4-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl)thiazol-2-ol (3.42 mmol, 1.03 g, 52%).

Provenance & Evidence