Trifluoromethanesulfonic acid → HCID 50940353, compound

Participants

Reaction Conditions

Reaction Steps

According to Scheme 2, Step 6: To a solution of 4-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl)-2-(pyrimidin-2-yloxy)thiazole (0.18 mmol, 67 mg) in TFA (1.8 mL) was added trifluoromethanesulfonic acid (1.77 mmol, 156 μl). The reaction mixture was stirred for 8 minutes at 80° C. under microwave conditions. The crude mixture was quenched with water and the aqueous phase was extracted with DCM. The organic layer was dried over MgSO4, was filtered and was evaporated to dryness. The crude residue was purified by preparative TLC using DCM/EtOH/NH3 (100:0:0 to 93:6.7:0.3) as eluent to yield 4-(5-methyl-1H-pyrazol-4-yl)-2-(pyrimidin-2-yloxy)thiazole (12 μmol, 3.2 mg, 7%) as a beige solid.

Provenance & Evidence