反应详情

According to Scheme 6, Step 1: A solution of 1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-bromoethanone (9.70 mmol, 3.00 g) and of thiourea (9.70 mmol, 739 mg) in acetone (20 mL) was stirred under reflux for 1 hour. After filtration and evaporation of the filtrate, the white solid was partitioned between EtOAc and a saturated solution of Na2CO3. The aqueous phase was extracted with EtOAc. The organic phase was dried over Na2SO4, was filtered and was concentrated to yield 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-2-amine (8.14 mmol, 2.33 g) as an orange foam.

1. temperatureunder reflux for 1 hour
2. filtrationAfter filtration and evaporation of the filtrate
3. customthe white solid was partitioned between EtOAc
4. extractionThe aqueous phase was extracted with EtOAc
5. dry with materialThe organic phase was dried over Na2SO4
6. filtrationwas filtered
7. concentrationwas concentrated