反应详情

温度

50 °C

In 15 ml of dioxane, 117 mg (0.2 mmol) of methyl {8-fluoro-2-[4-(3-fluorophenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydro-4-quinazolinyl}acetate (Example 34A) are mixed with 0.61 ml of 1N aqueous sodium hydroxide solution, and the mixture is stirred at 50° C. for 3 hours. After removal of the solvent, the residue is taken up in water and the mixture is adjusted to pH 3-4 using 1N hydrochloric acid. The precipitate is filtered off with suction, washed with water and dried under reduced pressure.

1. customAfter removal of the solvent
2. filtrationThe precipitate is filtered off with suction
3. washwashed with water
4. customdried under reduced pressure