Ethylamine → N-Ethyl-6-methyl-2-(methylsulfanyl)pyrimidin-4-amine
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[CH2:11]([NH2:13])[CH3:12]>O>[CH2:11]([NH:13][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1)[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50° C. for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amine (20 g, 90% yield).
Workup
- customAfter completion, excess ethylamine was evaporated on rotary evaporator under vacuum
- filtrationThe solid was filtered
- customdried under vacuum
Sources & evidence
- ORD record
- ord-da795f83080b47748b44e9a35a6e67b8
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08513266B2
Reaction notes
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