HCID 58451205, compound → HCID 57930767, compound

HRID 1893920Notes

Reaction equation

HRID 1893920 reaction equation
[CH:1]1([NH:7][C:8]2[C:13](/[CH:14]=[CH:15]/[C:16](OCC)=[O:17])=[C:12]([CH3:21])[N:11]=[C:10]([NH:22][CH2:23][CH3:24])[N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CC(O)=O>[CH:1]1([N:7]2[C:8]3[N:9]=[C:10]([NH:22][CH2:23][CH3:24])[N:11]=[C:12]([CH3:21])[C:13]=3[CH:14]=[CH:15][C:16]2=[O:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 58451205HCID 58451205, compound

Product 1

HCID 57930767HCID 57930767, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
186 °C

Procedure

(E)-ethyl 3-(4-(cyclohexylamino)-2-(ethylamino)-6-methylpyrimidin-5-yl)acrylate (200 mg, 0.6 mmol) was dissolved in AcOH (2 mL). This solution was heated in a sealed tube at 186° C. for 17 h. Standard workup and purification by column chromatography gave 65 mg (38% yield) of 8-cyclohexyl-2-(ethylamino)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one.

Workup

  1. customStandard workup and purification by column chromatography

Sources & evidence

ORD record
ord-6ba429b395334b26a559642fc65f0e9e
Source dataset
uspto-grants-2013_08
Patent number
US08513266B2

Reaction notes

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