4-(Phenylsulfonyl)aniline → 6-Chloro-4-(4-phenylsulphonylanilino)pyrido[3,4-d]pyrimidine

HRID 1893967Notes

Reaction equation

HRID 1893967 reaction equation
[C:1]1([S:7]([C:10]2[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:18]1[C:19]2[CH:27]=[C:26]([Cl:28])[N:25]=[CH:24][C:20]=2[N:21]=[CH:22][N:23]=1>>[C:1]1([S:7]([C:10]2[CH:16]=[CH:15][C:13]([NH:14][C:18]3[C:19]4[CH:27]=[C:26]([Cl:28])[N:25]=[CH:24][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:12][CH:11]=2)(=[O:8])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 5166664-(Phenylsulfonyl)anilineHCID 108218764,6-Dichloropyrido[3,4-d]pyrimidine

Product 1

HCID 219521656-Chloro-4-(4-phenylsulphonylanilino)pyrido[3,4-d]pyrimidine

Procedure

Prepared according to Procedure A from 4-benzenesulphonylaniline (Helv. Chim. Acta., 1983, 66 (4), 1046) and 4,6-dichloropyrido[3,4-d]pyrimidine; [2H6]-DMSO 9.09 (1H, s), 8.80-8.88 (2H, m), 8.19 (2H, d), 7.94-8.09 (4H, m), 7.53-7.20 (3H, m); m/z (M+1)+ 397.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ad3fb7871536429ca6a18db6cc559a33
Source dataset
uspto-grants-2013_08
Patent number
US08513262B2

Reaction notes

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