2-(Methylsulfonyl)ethanamine → HCID 9851149, compound

HRID 1893972Notes

Reaction equation

HRID 1893972 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][C:26]=1[O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([F:35])[CH:30]=1)[NH:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17]3[O:21][C:20]([CH:22]=O)=[CH:19][CH:18]=3)[CH:15]=2)[N:10]=[CH:9][N:8]=1.[CH3:36][S:37]([CH2:40][CH2:41][NH2:42])(=[O:39])=[O:38]>>[F:35][C:31]1[CH:30]=[C:29]([CH:34]=[CH:33][CH:32]=1)[CH2:28][O:27][C:26]1[CH:25]=[CH:24][C:5]([NH:6][C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]4[O:21][C:20]([CH2:22][NH:42][CH2:41][CH2:40][S:37]([CH3:36])(=[O:39])=[O:38])=[CH:19][CH:18]=4)[CH:15]=3)[N:10]=[CH:9][N:8]=2)=[CH:4][C:3]=1[O:2][CH3:1]

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 21952083HCID 21952083, compound

Product 1

HCID 9851149HCID 9851149, compound

Procedure

Prepared according to Procedure D from 5-(4-{3-methoxy-4-(3-fluorobenzyloxy)anilino}-6-quinazolinyl)-furan-2-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR 400 MHz (DMSO-d6) 9.22 (s, 1H); 8.78 (s, 1H); 8.31 (d, 1H); 7.88 (d, 1H); 7.50-7.08 (m, 8H); 6.84 (d, 1H); 5.13 (s, 2H); 4.42 (s, 2H); 3.80 (s, 3H); 3.60 (m, 2H); 3.40 (m, 2H, obscured by water peak); 3.10 (s, 3H); MS m/z 577 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-31d42b45010744dcb4eb48e0b1a5df3f
Source dataset
uspto-grants-2013_08
Patent number
US08513262B2

Reaction notes

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