4-Chlorophenyl chloroformate → HCID 11965615, compound

HRID 1894062Notes

Reaction equation

HRID 1894062 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:3].[CH3:12][O:13][C:14](=[O:31])[C:15]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][O:23][CH2:22]2)[C:18]([C:26]([F:29])([F:28])[F:27])=[CH:17][C:16]=1[NH2:30]>O1CCOCC1>[CH3:12][O:13][C:14](=[O:31])[C:15]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][O:23][CH2:22]2)[C:18]([C:26]([F:28])([F:29])[F:27])=[CH:17][C:16]=1[NH:30][C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:3]

Participants

4

Reactant 2

HCID 1390594-Chlorophenyl chloroformateHCID 11965614HCID 11965614, compound

Product 1

HCID 11965615HCID 11965615, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

4-Chlorophenyl chloroformate (27.3 μL, 1.1 equiv) was added to a solution of 2-amino-5-(tetrahydro-furan-3-yl)-4-trifluoromethyl-benzoic acid methyl ester (51.3 mg, 0.18 mmol) in dioxane (500 μL). The mixture was then stirred for 2 h (TLC control) at 80° C. The mixture was evaporated to dryness. The product was used in the next step without further purification. (rt 6.87 min.)

Workup

  1. customThe mixture was evaporated to dryness
  2. customThe product was used in the next step without further purification
  3. custom(rt 6.87 min.)

Sources & evidence

ORD record
ord-15a0920019124c9483c371014ee0d71f
Source dataset
uspto-grants-2013_08
Patent number
US08513268B2

Reaction notes

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