HRID1894153

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9015

4-Methoxyphenol

C7H8O2

HCID22392014

[5-(Methylsulfanyl)pyridin-3-yl]boronic acid

C6H8BNO2S

结构：COc1ccc(Oc2nc(-c3cncc(SC)c3)ncc2NC[C@@H]2CCCN2C(=O)OC(C)(C)C)cc1

HCID58247402

未命名化合物

PRODUCTS

生成物

结构：COc1cncc(-c2ncc(NC[C@@H]3CCCN3C(=O)OC(C)(C)C)c(Oc3cccc(O)c3)n2)c1

HCID67195574

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a same manner to Compound 1g in Example 1. Using an adaptation of the method described in Procedure A-D, substituting 3-Hydroxy-phenol for 4-Methoxyphenol in Procedure A and substituting 5-Methoxy-pyridin-3-yl boronic acid for Compound 1f in Procedure D, the title Compound 10a was obtained. MS: m/z 494.2 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-85e032f5f5f946038826684a65efa529
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08513271B2
来源说明: uspto-grants-2013_08

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:15]1[C:16]([O:29][C:30]2[CH:35]=[CH:34][C:33](OC)=[CH:32][CH:31]=2)=[N:17][C:18]([C:21]2[CH:22]=[N:23][CH:24]=[C:25](SC)[CH:26]=2)=[N:19][CH:20]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:38][O:39]C1C=CC(O)=CC=1.CSC1C=C(B(O)[OH:56])C=NC=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:15]1[C:16]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([OH:56])[CH:31]=2)=[N:17][C:18]([C:21]2[CH:22]=[N:23][CH:24]=[C:25]([O:39][CH3:38])[CH:26]=2)=[N:19][CH:20]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]