Benzyl (4-hydroxyphenyl)carbamate → 4-Methoxyphenol

HRID 1894155Notes

Reaction equation

HRID 1894155 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=2)[C:5]([NH2:17])=[CH:4][N:3]=1.[CH2:18]([O:25][C:26](=[O:35])[NH:27][C:28]1[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:6][O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.[CH2:18]([O:25][C:26](=[O:35])[NH:27][C:28]1[CH:29]=[CH:30][C:31]([O:34][C:4]2[C:5]([NH2:17])=[CH:6][N:7]=[C:2]([Cl:1])[N:3]=2)=[CH:32][CH:33]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 293061Benzyl (4-hydroxyphenyl)carbamateHCID 58243054HCID 58243054, compound

Product 2

HCID 90154-MethoxyphenolHCID 58247429HCID 58247429, compound

Procedure

The title compound was prepared in a same manner to Compound 1c in Example 1. Using an adaptation of the method described in Procedures A and B, substituting (4-hydroxy-phenyl)-carbamic acid benzyl ester (prepared according to the procedure disclosed in U.S. Pat. No. 3,933,470) for 4-methoxyphenol in Procedure A, the title Compound 11a was obtained. MS: m/z 371.2 (M+H)+.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-0b1b8e801e0349308941966cc45d5719
Source dataset
uspto-grants-2013_08
Patent number
US08513271B2

Reaction notes

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