4-Methoxyphenol → HCID 58247399, compound

HRID 1894171Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:15]1[C:16]([O:22][C:23]2[CH:28]=[CH:27][C:26](OC)=[CH:25][CH:24]=2)=[N:17][C:18]([Cl:21])=[N:19][CH:20]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:31][O:32]C1C=CC(O)=CC=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:13][NH:14][C:15]1[C:16]([O:22][C:23]2[CH:28]=[CH:27][C:26]([CH2:31][OH:32])=[CH:25][CH:24]=2)=[N:17][C:18]([Cl:21])=[N:19][CH:20]=1)=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

Reactant 2

HCID 90154-Methoxyphenol

HCID 582430462-(S)-{[2-Chloro-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 58247399HCID 58247399, compound

Procedure

The title compound was prepared in a same manner to Compound 1e in Example 1. Using an adaptation of the method described in Procedures A-C, substituting 4-hydroxymethyl-phenol for 4-methoxyphenol in Procedure A, the title Compound 18a was obtained. MS: m/z 435.2 (M+H)+.

Sources & evidence

ORD record: ord-0dad5410ebcf4e3ebd32b411fd487850
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513271B2

Reaction notes

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