反应详情

温度

150 °C

A mixture of 6-(4-fluoro-phenyl)-3-iodo-pyrazolo[1,5-a]pyridine (150 mg, 0.44 mmol), 3-([1,3,4]thiadiazol-2-ylamino)-phenyl boronic acid pinacol ester (190 mg, 0.62 mmol) and PdCl2ddpf (32 mg, 0.04 mmol) in DME (1.5 ml) and 2N Na2CO3 (aq, 1.5 ml) in a microwave vial was deoxygenated by bubbling N2 through for 30 seconds. The vial was sealed and then stirred and heated at 150° C. in the microwave for 30 minutes. After cooling to RT the mixture was partitioned between CH2Cl2/H2O. The organic layer was evaporated and the residue was purified by preparative HPLC to give the title compound (15 mg, solid).

1. custom2N Na2CO3 (aq, 1.5 ml) in a microwave vial was deoxygenated
2. customby bubbling N2 through for 30 seconds
3. customThe vial was sealed
4. temperatureAfter cooling to RT the mixture
5. customwas partitioned between CH2Cl2/H2O
6. customThe organic layer was evaporated
7. customthe residue was purified by preparative HPLC