Methyl iodide → HCID 58464069, compound

HRID 1894263Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[CH:12][C:13]([N:16]3[CH2:21][CH2:20][C:19]([CH3:23])([CH3:22])[NH:18][C:17]3=[O:24])=[N:14][CH:15]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:25]I>>[F:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[CH:12][C:13]([N:16]3[CH2:21][CH2:20][C:19]([CH3:22])([CH3:23])[N:18]([CH3:25])[C:17]3=[O:24])=[N:14][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 58464039HCID 58464039, compound

Product 1

HCID 58464069HCID 58464069, compound

Procedure

The title compound, a light yellow solid, MS: m/e=339.1 (M+H+), was prepared in accordance with the general method of Example 165, by alkylation of 1-(5-((3-fluorophenyl)ethynyl)pyrazin-2-yl)-4,4-dimethyltetrahydropyrimidin-2(1H)-one (Example 166) with methyl iodide.

Sources & evidence

ORD record: ord-3bd9b7b2baa149ae962b9bea3e39ffb2
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513273B2

Reaction notes

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