4-Fluorobenzylamine → HCID 11708802, compound

HRID 1894282Notes

Reaction equation

HRID 1894282 reaction equation
Cl[C:2]1[C:7]2[C:8]([CH3:12])=[C:9]([CH3:11])[NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>>[CH3:11][C:9]1[NH:10][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:19][CH2:18][C:17]3[CH:20]=[CH:21][C:14]([F:13])=[CH:15][CH:16]=3)[C:7]=2[C:8]=1[CH3:12]

Participants

3

Reactant 2

HCID 673264-FluorobenzylamineHCID 714120514-Chloro-2,3-dimethyl-1H-pyrrolo[3,2-c]pyridine

Product 1

HCID 11708802HCID 11708802, compoundYield 83.2%

Conditions

Temperature
160 °C

Procedure

A mixture of 4-chloro-2,3-dimethyl-1H-pyrrolo[3,2-c]pyridine (1.16 g, 6.43 mmol) prepared in Preparation 1 and 4-fluorobenzylamine (3 ml, 26.2 mmol) was stirred for 12 hours at 160° C. The reaction mixture was cooled to room temperature and purified with silica gel column chromatography (ethyl acetate: 100%) to give the titled compound as a white solid. (Yield: 83.2%)

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. custompurified with silica gel column chromatography (ethyl acetate: 100%)

Sources & evidence

ORD record
ord-a9399e05fe6249eb9d2c6a425b4158e7
Source dataset
uspto-grants-2013_08
Patent number
US08513277B2

Reaction notes

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