1,2,3,4-Tetrahydroisoquinoline → HCID 11515887, compound

HRID 1894287Notes

Reaction equation

HRID 1894287 reaction equation
[CH2:1]([C:8]1[C:12]2[C:13](Cl)=[N:14][CH:15]=[CH:16][C:11]=2[NH:10][C:9]=1[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][NH:20]1>>[CH2:1]([C:8]1[C:12]2[C:13]([N:20]3[CH2:21][CH2:22][C:23]4[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:19]3)=[N:14][CH:15]=[CH:16][C:11]=2[NH:10][C:9]=1[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 707004383-Benzyl-4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine

Product 1

HCID 11515887HCID 11515887, compoundYield 89.7%

Procedure

In accordance with the same procedures as Example 1, except for using 3-benzyl-4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine prepared in Preparation 2 and 1,2,3,4-tetrahydroisoquinoline, the titled compound was obtained as a pale yellow solid. (Yield: 89.7%).

Sources & evidence

ORD record
ord-3822e1a1b2f74a14b2a1cb8175e832bf
Source dataset
uspto-grants-2013_08
Patent number
US08513277B2

Reaction notes

Loading…