1,2,3,4-Tetrahydroisoquinoline → HCID 11551837, compound

HRID 1894299Notes

Reaction equation

HRID 1894299 reaction equation
[CH2:1]([C:4]1[C:8]2[C:9]([Cl:13])=[N:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]=1[CH3:14])[CH:2]=[CH2:3].[CH2:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][NH:16]1>>[ClH:13].[CH2:1]([C:4]1[C:8]2[C:9]([N:16]3[CH2:17][CH2:18][C:19]4[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH2:15]3)=[N:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]=1[CH3:14])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 86226271HCID 86226271, compound

Product 1

HCID 11551837HCID 11551837, compoundYield 77.4%

Procedure

In accordance with the same procedures as Examples 1 and 2, except for using 3-allyl-4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine prepared in Preparation 4 and 1,2,3,4-tetrahydroisoquinoline, the titled compound was obtained as a pale yellow solid. (Yield: 77.4%)

Sources & evidence

ORD record
ord-7c6029d512d247fdb4dc4280f5dd4179
Source dataset
uspto-grants-2013_08
Patent number
US08513277B2

Reaction notes

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