HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Lucitanib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Reactant | HCID 24905361 | HCID 24905361 | — |
| Solvent | Water ethylacetate | HCID 22728543 | — |
| Product | Lucitanib | HCID 25031915 | — |
Reaction Steps
The product of Example 1 (100 mg) was mixed with acetic acid (1 ml) and 33% HBr/acetic acid (0.6 ml). The reaction was stirred at RT for 1 hour and diluted with EtOAc/H2O then basified with Na2CO3. The organic layer was dried, evaporated and purified with silica gel column to give the titled product. Mass: (M+1), 444
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513283B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-ba51d87e3e5b49fb8cbe7fdc0624b9c6 |
| Source note | uspto-grants-2013_08 |