[1,4'-Bipiperidin]-3-ol → [2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-(3-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	[1,4'-Bipiperidin]-3-ol	HCID 21091574	—
Reactant	rac-(4S,5R)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 76588520	—
Product	[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-(3-hydroxy-[1,4']bipiperidinyl-1'-yl)-methanone	HCID 25262576	—

Reaction Steps

In a manner analogous to the method described in example 3, rac-(4S*,5R*)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 3-hydroxy-[1,4′]bipiperidine (ChemBridge) to give the title compound as a racemic mixture. HR-MS (ES, m/z) calculated for C38H49N6O3Cl2 [(M+H)+] 707.3238, observed 707.3232.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513239B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-cfe8f1ffa05e4e48a291b58873964ad6
Source note	uspto-grants-2013_08