3-Hydroxypiperidine → [2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-(3-hydroxy-piperidin-1-yl)-methanone

Participants

Role	Name	HCID	Charge
Reactant	3-Hydroxypiperidine	HCID 23293	—
Reactant	rac-(4S,5R)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 76588520	—
Product	[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-(3-hydroxy-piperidin-1-yl)-methanone	HCID 25262733	—

Reaction Steps

In a manner analogous to the method described in example 3, rac-(4S*,5R*)-2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 3-hydroxy-piperidine (TCI America) to give the title compound as a racemic mixture. HR-MS (ES, m/z) calculated for C33H40N5O3Cl2 [(M+H)+] 624.2503, observed 624.2502.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513239B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-449a819e8ed341328159501dde2e104e
Source note	uspto-grants-2013_08