2-(Piperazin-1-yl)acetamide dihydrochloride → 2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(Piperazin-1-yl)acetamide dihydrochloride	HCID 17750375	—
Reactant	rac-(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 76588499	—
Product	2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide	HCID 25260864	—

Reaction Steps

In a manner analogous to the method described in examples 8, rac-(4S*,5R*)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 7) was coupled with 2-piperazin-1-yl-acetamide dihydrochloride (Matrix Scientific) to give the title compound as a racemic mixture. HR-MS (ES, m/z) calculated for C35H43N6O3Cl2 [(M+H)+] 665.2768, observed 665.2767.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513239B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-482fd03fba054c6f83fe51108f9ef73e
Source note	uspto-grants-2013_08