HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-cyclopropyl-2-(piperazin-1-yl)propanamide → HCID 25261675, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-cyclopropyl-2-(piperazin-1-yl)propanamide | HCID 16227404 | — |
| Reactant | (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride | HCID 57669958 | — |
| Product | HCID 25261675 | HCID 25261675 | — |
Reaction Steps
In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with N-cyclopropyl-2-piperazin-1-yl-propionamide (Enamine) to give the title compound as a mixture of diastereomers. HR-MS (ES, m/z) calculated for C39H49Cl2N6O3 [(M+H)+] 719.3238, observed 719.3244.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513239B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-6498e366bd8a4b9685c339bab2314279 |
| Source note | uspto-grants-2013_08 |