反应详情

To a solution of methanesulfonic acid 3-pyridin-4-yl-propyl ester (6.5 g, 30.19 mmol) in methanol (150 mL) was added sodium thiomethoxide (6.35 g, 90.57 mmol, Aldrich). The mixture was stirred at room temperature for 1 h then concentrated in vacuo. The residue was diluted with ethyl acetate and washed with water (2×), brine (1×), dried over anhydrous sodium sulfate and concentrated to give 4-(3-methylsulfanyl-propyl)-pyridine as dark brown oil (2.24 g).

1. concentrationthen concentrated in vacuo
2. additionThe residue was diluted with ethyl acetate
3. washwashed with water (2×), brine (1×)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated