1-(Tetrahydro-2-furoyl)piperazine → HCID 25262900, compound

Participants

Reaction Steps

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with piperazin-1-yl-(tetrahydro-furan-2-yl)-methanone (Alfa) to give the title compound as a mixture of diastereomers. HR-MS (ES, m/z) calculated for C38H46Cl2N5O4 [(M+H)+] 706.2922, observed 706.2918.

Provenance & Evidence