Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate → HCID 57670036, compound

HRID 1894453Notes

Reaction equation

HRID 1894453 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32](Cl)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:35][CH2:36][CH3:37])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:38]([O:40][C:41]([CH:43]1[C@@H:48]2[C@H:44]1[CH2:45][NH:46][CH2:47]2)=[O:42])[CH3:39]>>[CH2:38]([O:40][C:41]([CH:43]1[C@@H:48]2[C@H:44]1[CH2:45][N:46]([C:32]([N:12]1[C@@:13]([C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=3)([CH3:24])[C@@:14]([C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)([CH3:16])[N:15]=[C:11]1[C:8]1[CH:9]=[N:10][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:6][C:7]=1[O:35][CH2:36][CH3:37])=[O:33])[CH2:47]2)=[O:42])[CH3:39]

Participants

3

Reactant 2

HCID 1514453Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylateHCID 57669958(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 57670036HCID 57670036, compound

Procedure

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with (1S,5R)-3-aza-bicyclo-[3.1.0]hexane-6-carboxylic acid ethyl ester (Tyger Scientific) to give the title compound. HR-MS (ES, m/z) calculated for C37H43Cl2N4O4 [(M+H)+] 677.2656, observed 677.2655.

Sources & evidence

ORD record
ord-8ef135ef5005417a87772a276421083c
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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