Ethyl (1,4-diazepan-1-yl)acetate → HCID 67205518, compound

Participants

Reaction Steps

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with homopiperazine-acetic acid ethyl ester to give 2-{4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-[1,4]diazepan-1-yl}-acetic acid ethyl ester. The ester was hydrolyzed, then the corresponding acid was treated with amonium chloride to give the title compound. HR-MS (ES, m/z) calculated for C36H45Cl2N6O3 [(M+H)+] 679.2925, observed 679.2927.

Provenance & Evidence