1-Ethyl-4-piperidin-4-ylpiperazine → [(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(4-ethyl-piperazin-1-yl)-piperidin-1-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	1-Ethyl-4-piperidin-4-ylpiperazine	HCID 535780	—
Reactant	(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 57669958	—
Product	[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(4-ethyl-piperazin-1-yl)-piperidin-1-yl]-methanone	HCID 57669973	—

Reaction Steps

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with 1-ethyl-4-piperidin-4-yl-piperazine (Matrix) to give the title compound. HR-MS (ES, m/z) calculated for C40H53Cl2N6O2 [(M+H)+] 719.3602, observed 719.3606.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513239B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-c28318fe9fae450dbbf9d6e2c07bbeb2
Source note	uspto-grants-2013_08