HCID 20569916, compound → HCID 57669982, compound

HRID 1894476Notes

Reaction equation

[CH3:1][N:2]([CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[S:3]([CH3:6])(=[O:5])=[O:4].[C:13]([C:17]1[N:22]=[CH:21][C:20]([C:23]2[N:24]([C:44](Cl)=[O:45])[C@@:25]([C:37]3[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][CH:38]=3)([CH3:36])[C@@:26]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)([CH3:28])[N:27]=2)=[C:19]([O:47][CH2:48][CH3:49])[CH:18]=1)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([C:17]1[N:22]=[CH:21][C:20]([C:23]2[N:24]([C:44]([N:10]3[CH2:9][CH2:8][CH:7]([N:2]([CH3:1])[S:3]([CH3:6])(=[O:5])=[O:4])[CH2:12][CH2:11]3)=[O:45])[C@@:25]([C:37]3[CH:38]=[CH:39][C:40]([Cl:43])=[CH:41][CH:42]=3)([CH3:36])[C@@:26]([C:29]3[CH:30]=[CH:31][C:32]([Cl:35])=[CH:33][CH:34]=3)([CH3:28])[N:27]=2)=[C:19]([O:47][CH2:48][CH3:49])[CH:18]=1)([CH3:14])([CH3:15])[CH3:16]

Participants

Reactant 2

HCID 20569916HCID 20569916, compound

HCID 57669958(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 57669982HCID 57669982, compound

Procedure

In a manner analogous to the method described in example 8, N-Methyl-N-piperidin-4-yl-methanesulfonamide from above was reacted with (4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) to give the title compound. HR-MS (ES, m/z) calculated for C36H46Cl2N5O4S [(M+H)+] 714.2642, observed 714.2636.

Sources & evidence

ORD record: ord-ee3545b084c24d7d9c8c734267447835
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513239B2

Reaction notes

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