Ethanamine, 2-(methylsulfonyl)-, hydrochloride (1:1) → HCID 57669943, compound

HRID 1894489Notes

Reaction equation

HRID 1894489 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][CH2:38][CH:37]([C:40]([OH:42])=O)[CH2:36][CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:43][CH2:44][CH3:45])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:47][CH2:48][CH2:49][S:50]([CH3:53])(=[O:52])=[O:51]>>[CH3:53][S:50]([CH2:49][CH2:48][NH:47][C:40]([CH:37]1[CH2:38][CH2:39][N:34]([C:32]([N:12]2[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=[C:11]2[C:8]2[CH:9]=[N:10][C:5]([C:1]([CH3:2])([CH3:4])[CH3:3])=[CH:6][C:7]=2[O:43][CH2:44][CH3:45])=[O:33])[CH2:35][CH2:36]1)=[O:42])(=[O:52])=[O:51]

Participants

3

Reactant 2

HCID 17749886Ethanamine, 2-(methylsulfonyl)-, hydrochloride (1:1)HCID 57669951HCID 57669951, compound

Product 1

HCID 57669943HCID 57669943, compound

Procedure

In a manner analogous to the method described in example 163, 1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidine-4-carboxylic acid, was coupled with 2-aminoethyl methylsulfone hydrochloride (Array) to give the title compound. HR-MS (ES, m/z) calculated for C38H48Cl2N5O5S [(M+H)+] 756.2748, observed 756.2749.

Sources & evidence

ORD record
ord-ed404a82fade4ae89af8f8ad482ae9ba
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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