HCID 22609743, compound → HCID 57670037, compound

HRID 1894490Notes

Reaction equation

HRID 1894490 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][CH2:38][CH:37]([C:40](O)=[O:41])[CH2:36][CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28](Cl)=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:43][CH2:44][CH3:45])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:46].[CH3:47][S:48]([CH2:51][CH2:52][NH:53][CH3:54])(=[O:50])=[O:49]>>[CH3:47][S:48]([CH2:51][CH2:52][N:53]([CH3:54])[C:40]([CH:37]1[CH2:38][CH2:39][N:34]([C:32]([N:12]2[C@@:13]([C:25]3[CH:26]=[CH:27][C:28]([Cl:46])=[CH:29][CH:30]=3)([CH3:24])[C@@:14]([C:17]3[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=3)([CH3:16])[N:15]=[C:11]2[C:8]2[CH:9]=[N:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][C:7]=2[O:43][CH2:44][CH3:45])=[O:33])[CH2:35][CH2:36]1)=[O:41])(=[O:50])=[O:49]

Participants

3

Reactant 2

HCID 22609743HCID 22609743, compoundHCID 57669951HCID 57669951, compound

Product 1

HCID 57670037HCID 57670037, compound

Procedure

In a manner analogous to the method described in example 163, 1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidine-4-carboxylic acid was coupled with (2-methanesulfonylethyl)-methylamine hydrochloride (Array) to give the title compound. HR-MS (ES, m/z) calculated for C39H50Cl2N5O5S [(M+H)+] 770.2904, observed 770.2905.

Sources & evidence

ORD record
ord-e6f26328644140b6bc53e8b29ec77f9a
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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