N-Methyl-D-glucamine → HCID 57670066, compound

HRID 1894503Notes

Reaction equation

HRID 1894503 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32](Cl)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:35][CH2:36][CH3:37])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:38][NH:39][CH2:40][C@H:41]([OH:50])[C@@H:42]([OH:49])[C@H:43]([OH:48])[C@H:44]([OH:47])[CH2:45][OH:46]>>[CH3:38][N:39]([CH2:40][C@H:41]([OH:50])[C@@H:42]([OH:49])[C@H:43]([OH:48])[C@H:44]([OH:47])[CH2:45][OH:46])[C:32]([N:12]1[C@@:13]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)([CH3:24])[C@@:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)([CH3:16])[N:15]=[C:11]1[C:8]1[CH:9]=[N:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][C:7]=1[O:35][CH2:36][CH3:37])=[O:33]

Participants

3

Reactant 2

HCID 8567N-Methyl-D-glucamineHCID 57669958(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 57670066HCID 57670066, compound

Procedure

In a manner analogous to the method described in examples 8, (4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride (example 51) was coupled with (2R,3R,4R,5S)-6-methylamino-hexane-1,2,3,4,5-pentaol (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C36H47Cl2N4O7 [(M+H)+] 717.2817, observed 717.2813.

Sources & evidence

ORD record
ord-e99238029afd4d97a9efed89d1a42770
Source dataset
uspto-grants-2013_08
Patent number
US08513239B2

Reaction notes

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