反应详情

A solution of {1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-carbamic acid tert-butyl ester (220 mg, 0.304 mmole, example 203) in dichloromethane (6 mL) was treated with trifluoroacetic acid (6 mL) at 0° C. and allowed to stir for 2 h before concentrated to dryness under reduced pressure. The residue was then taken up in dichloromethane (100 mL), washed with aqueous sodium carbonate (2×15 mL), water (15 mL) and concentrated to give the title compound (174 mg). HR-MS (ES, m/z) calculated for C34H42Cl2N5O2 [(M+H)+] 622.2710, observed 622.2714.

1. concentrationbefore concentrated to dryness under reduced pressure
2. washwashed with aqueous sodium carbonate (2×15 mL), water (15 mL)
3. concentrationconcentrated