2-Methylpyrrolidine → HCID 57669962, compound

Participants

Reaction Steps

In a manner analogous to the method described in example 163, {1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acid was coupled with 2-methyl-pyrrolidine (Aldrich) to give the title compound as a mixture of diastereomers. HR-MS (ES, m/z) calculated for C41H52Cl2N5O3 [(M+H)+] 761.3707, observed 761.3707.

Provenance & Evidence